Why the reproduction of cancer cells will be out of control
Researchers at Mcgill University in Canada have shown that a member of the protein family known as SUMO (small ubiquitin like modification) is the key to the control of tumor cell reproduction, especially in glioblastoma.
SUMO protein modification of other proteins and protein SUMO is essential for many cellular processes, to identify the role of SUMO in cancer cell growth will lead to new strategies for the treatment of glioblastoma.
Glioblastoma is the most common fatal brain cancer. Current standard treatments include surgical resection, postoperative adjuvant chemotherapy and radiotherapy. Despite treatment, patients can only survive about a year and a half. Cancer continues to grow in part because of the existence of cancer stem cells. Understanding the pathways of cancer growth in stem cells is essential for the development of targeted therapy for stem cells.
The molecular mechanisms that control the growth of cancer through the cell cycle process, the large number of proteins involved in this process and many aspects are still unknown. Cell cycle protein dependent kinases (CDKs) are a group of proteins that drive cell cycle; however, it is not clear why cancer cells maintain a large number of CDK proteins.
"In the study of the cell cycle of human glioblastoma, we found that CDK6 was modified by SUMO1. SUMO modification of CDK6 inhibits its degradation, thereby stabilizing the CDK6 protein in cancer, "said Dr. Bellail Anita, the lead author of the paper.
"We found that SUMO's CDK6 is essential for the reconstruction and growth of cancer stem cells in glioblastoma. Inhibition of SUMO1 eliminates the development of stem cells and the inhibition of cancer."
Their findings add to the recent study of the SUMO pathway in the development of human tumors and the occurrence and development of the study. With a new understanding of how SUMO affects the cell cycle in cancer stem cells, this group of scientists is currently screening SUMO1 for the treatment of human glioblastoma.