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The little fat man looks at the immune cells that control the body weight

2016-07-19 14:03:26 Suzhou Mingchem Pharmtech Co., Ltd Read

Researchers from the United States in an early study confirmed that some of the immune system cells are likely to play an important role in weight control. The study, published in the December 22nd "nature" (Nature) magazine, and was selected to Nature web site news headlines.

Researchers from the United States in an early study confirmed that some of the immune system cells are likely to play an important role in weight control. The study, published in the December 22nd "nature" (Nature) magazine, and was selected to Nature web site news headlines.

Although scientists have long known that some of the immune cells in mice may help prevent the occurrence of obesity, the results of the new study are the first to show that this is also the case in humans.

The researchers found that, compared to lean, not obese adults in abdominal fat of a common immune cells known as ILC2s. And in some experiments with mice, they found that ILC2s appears to promote the "Beige" (Beige) fat cell formation, we know that the latter can improve the body's calorie burning.

Senior researcher, Weill Cornell Medical College (Weill Cornell Medical College, Professor of immunology at David artis said seems to these ilc2 cells cannot in obese subjects normally.

Artis said that it is not clear exactly why this situation or mechanism, but these are the key issues of future research. He hopes to eventually develop some new methods to solve the obesity problem.

In the past few years, researchers have only begun to understand the mechanisms by which the immune system affects metabolism and weight control (extended reading: Cell: treatment of obesity), according to Artis. This may sound surprising, because the most known function of the immune system is to help the body fight off infection. But from an evolutionary point of view, it makes sense.

Although the immediate task of the immune system is to fight infection, it is conceivable that some of the elements have evolved to have the ability to "communicate" with adipose tissue in the face of adversity, thereby altering the body's metabolism.

"You can imagine that it actually tells the adipose tissue that 'we're going to be in a bad time for a while and let's get used to it,'" Artis said.

The new study adds to the evidence that the immune system plays a role in body weight control, an obesity researcher who was not involved in the study said.

"This is really interesting," said Dr. Billington Charles, a spokesman for the American Obesity Association at the University of Minnesota. The association between immune function and metabolism is not a new concept. When people are injured or produce an allergic reaction, the body tends to enter the "metabolic hyperthyroidism" state, to accelerate the burning of calories.

Billington said, but the study and other recent studies have revealed that the immune system affects metabolism, and has the potential to affect long-term weight control mechanisms.

But he also stressed that there are a lot of unknown. "There is some overlap between the immune system and metabolism, and we don't really understand it."

ILC2s is seen as a group of immune cells that can help fight infection and play a role in allergy. Artis and colleagues want to know if these cells are still working on other jobs.

The researchers started with a study of abdominal fat samples from adults with obesity and normal weight, and the results confirmed that fat from the obese group had less ILC2s like the obese mice in the laboratory.

Subsequently, the researchers tested the injection of interleukin -33 (IL-33) on laboratory mice. IL-33 is an immune system protein that acts as a chemical messenger between cells ".

The study authors found that this treatment can increase the ILC2s of white fat in animals and instead increase calorie burning.

White fat is a capable of storing excess calories, fat type, its always shows for the beer belly or the waist fat, Billington explains. And another type of fat called brown fat, which occupies only a small body, can burn calories.

Scientists have long been searching for a way to increase the brown fat, Artis said. But the body in white fat and brown fat, there are third types of fat called beige fat.

Like brown fat, beige fat which burns calories and generate heat. More importantly, Artis says, it has the potential to play an important role in preventing obesity.

In the team's experiments, ilc2 cells as if by promoting animal storage Beige fat and improve the burn calories.

What does this mean for humanity?

Artis said: "it is clear that we are still in the early stages of the study, there is still a lot of work to do. And our goal is to develop a new approach to the treatment of obesity by a better understanding of the communication between the immune system and body fat."

But Billington thinks, this will be a long way. He pointed out that a big problem: since some cells of the immune system and take the number of work, how can you let them just increase Beige fat, instead of doing something you didn't want to happen, things such as allergic reaction?

In the larger picture, the study of obesity has made it clear that one thing: metabolic and weight control are complex. "It is impossible to have any" a ready-made panacea 'to fight obesity, "Billington said.

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