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Treatment of heart disease with 3D printing artery

2016-07-19 14:01:21 Suzhou Mingchem Pharmtech Co., Ltd Read

Biological Qualcomm reported: February 2016, the Wake Forest Baptist Medical Center for regenerative medicine scientists confirmed, using a complex, in particular custom 3D printer to print out the living tissue structure in patients with implanted and replace injured or diseased tissue. This study made the journal Nature Biotechnology, the magazine (3D printing organ transplants no longer distant) table.

Recently, doctors and engineers at the Melbourne University, Australia, used a super computer to prepare a three-dimensional model for heart disease, based on a photograph taken by a camera that is thinner than a human hair. In an academic paper published in the Heart Journal European in February 22nd, the researchers describe the potential applications of supercomputers in personalized medicine.

These images were collected during routine angiography and were then entered into the computer. In 24 hours, you can 3D print out a person's artery model. This gives heart disease experts a key message about the "blood flow behavior and the internal structure of the arteries". It also helps heart disease experts to make decisions about "inserting the best stent (device for opening the contraction or blocking the arteries)".

This technique can also detect the "hot spots" of arterial plaque, which is a waxy substance accumulated in the arteries, which can lead to heart disease. Using traditional techniques, it has been difficult to find some of these patches.

In Australia, heart disease is still the number one killer, affecting one in every six adults. Every nine minutes, there will be a person suffering from a heart attack. To alleviate this situation, it is essential to develop new techniques to predict plaque accumulation in the heart.

Barlis Peter, an associate professor at Melbourne University and an associate professor of the, is a heart disease scientist. He pointed out: "use our super sensitive heart scan, using a combination of super computer models derived from the model, we are now able to print out patient arterial segments, and hope that the custom is very suitable for them."

"There are no arteries of the same shape. We are all different, with different branches and sizes of the arteries, from the thicker gradually thinner. Like the debris accumulated along the banks of the river, the plaque can be attached to a certain area of the artery. So this technology really gives us a clear picture of the area."

"Ideally, we would like to use the model to predict the best stent type for the patient. Once the process has been streamlined, we can have a patient table, the artery for three-dimensional printing and modeling to guide the surgical procedures."

Determine which plaque causes heart attacks, is still the "Holy Grail of cardiology". He said: "with a ultra high resolution camera, known as optical coherence tomography (OCT), to scan the inside of the heart's arteries, simplifies the cholesterol plaque imaging. But it is still not clear the plaques which can lead to a heart attack. If we can identify these high-risk plaques more accurately, we can prevent a heart attack before they can occur."

Barlis introduced OCT to Australia in 2009 and has been improving the technology to benefit patients since. 3D modeling, he says, has a great potential to predict where plaque might form, and will eventually help doctors predict a heart attack.

Thondapu Vikas, PhD, a researcher at the Melbourne University, said the risk of plaque is a clue to the disorder in some of the blood flow patterns. "Our work is to use a supercomputer to simulate the blood flow in the arteries," Dr. Thondapu said. Our goal is to use blood flow patterns and disturbances to predict the future development of high risk plaques."

Barlis and his team now and engineering cooperation two arc projects, looking for a with biocompatible polymers, 3D printing and body structure and accurate matching of the heart stent, thereby reducing the risk of stent collapse or complications. They are also very concerned about the new polymers that can slowly collapse over time to allow the drug to be delivered directly to the patch.

In addition to the new 3D printing strategy proposed by this study, there are other research institutions to innovate and improve the 3D printing. For example, in November 2015, Northeastern University researchers developed an innovative 3D printing technology, using magnetic field will be composite, plastic and ceramic hybrid structure, shape into patient specific products. Related research results published in the "Communications Nature" (New 3D printing method to achieve personalized medicine). Over the same period, from Tsinghua University and the Drexel University scientists developed a method of 3D printing, can be prepared by a highly consistent, embryonic stem cells "modules". The results of the study were published in the November 2015 "Biofabrication" magazine (Tsinghua people's plan: a new type of cell 3D printing). We believe that with the continuous development and improvement of 3D printing technology, it will be more and more extensive in the field of biomedical development.

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